FIG 1. A–D, In the early phase of the disease (subject B3: 35-year-old woman), multiple, small lesions are found in the centrum semiovale (mainly in the frontal lobe) (A). In a later stage (subject B4: 61-year-old woman), confluent lesions are typically found in the white matter of the centrum semiovale (B), the frontal horns and trigones (C), and the internal and external capsule (D)