FIG 1. MR images of patient 6 with PMD arising from PLP duplication (classic form) obtained when the patient was 3 years old.

A, Transverse T1-weighted image shows high signal intensity in the posterior limb of the internal capsule (arrow) and optic radiation, representing myelination. T1 shortening was also recognized in the bilateral thalamus.

B, Transverse T2-weighted image shows abnormal high signal intensity in the diffuse cerebral white matter, representing hypomyelination, and low signal in the posterior limb of the internal capsule (white arrow), representing myelination. Low signal intensity was recognized in the bilateral striatum and thalamus.