FIG 1. Representative images of the three grades of lesions in cerebral and insular subcortex white matter regions. Grade 0 is not included and contains no hyperintensities. Grade 1 has minimal changes, Grade 2 involves mild changes, and Grade 3 indicates moderate-to-severe changes, thought to be significant indicators of a possible pathologic process. Arrowheads point to rated T2-weighted hyperintensities.

Top panel, Cerebral white matter hyperintensities (Grade 3 image has too many large hyperintensities to be defined by arrowheads).

Lower panel, hyperintensities in the insular subcortex white matter region.