FIG. 4. Histopathologic findings of the ipsilateral parietal cortices of the control and experimental rats (H and E, original magnification x400).

A, Light micrograph of a parietal cortex section from a control rat (group A) shows intact neurons (arrowheads) and well-preserved cell density 48 hours after CCA ligation.

B, Light micrograph of a parietal cortex section from a rat with the transient ADC reduction pattern (group C-1) shows neuronal loss with ischemic changes (cytoplasmic eosinophilia and pyknotic nuclei, arrows) 48 hours after the hypoxic/ischemic insult.

C, Light micrograph of a parietal cortex section from a rat with the biphasic ADC reduction pattern (group C-2) shows pan-cellular necrosis, indicative of cerebral infarction, 48 hours after the hypoxic/ischemic insult.

D, Light micrograph of a parietal cortex section from a rat with the persistent ADC reduction pattern (group C-3) shows cerebral infarction with extensive neuronal pyknosis (thick arrows) and severe neuropilar microvacuolation (thin arrow) 6 hours after the hypoxic/ischemic insult.