FIG 1. Axial quantitative MTR image of the brain in a patient with MS, obtained at level of the roof of the lateral ventricles. A and B, The slice is shown before (A) and after (B) manual image segmentation, which precedes any MTR histographic analysis to exclude all extracranial tissues.

C, The same slice is shown after postprocessing (see Methods); only the cortical/subcortical brain tissue is left to enter the MTR histographic analysis.