FIG 2. B, MR image before contrast administration (top left) and six dynamic contrast-enhanced MR images of a grade 4 glioblastoma multiforme. Top center, 15 seconds; top right, 45 seconds; middle left, 75 seconds; middle center, 105 seconds; middle right, 135 seconds; and lower left, 165 seconds after contrast administration. From these seven images, spatial maps of fBV and k^PS were determined: fBV (lower center) was estimated as 3.0% in the tumor rim and as 0.01% in the core. k^PS values (lower right) were 13.6 mL/100 cm³ per minute in the tumor (compared with 0.5 mL/100 cm³ per minute in the core). Times are defined as the time after contrast that the center of k-space (mid-part of 3D acquisition) was attained.