FIG 4. Patient with diffuse involvement from lung cancer, with patchy hyperintensity on diffusion-weighted images.

A, Sagittal T1-weighted image shows diffuse hypointensity throughout all visualized vertebral bodies.

B, Corresponding T2-weighted image shows patchy areas of hyperintensity mixed with hypointense regions.

C, Corresponding diffusion-weighted image shows patchy signal intensity throughout the vertebrae. The areas of increased signal intensity correspond to those seen on the T2-weighted image and, although more obvious on the diffusion-weighted image, the diffuse nature of disease is better seen on the T1-weighted image. The areas of hyperintensity on diffusion-weighted images are probably at least partially accounted for by shine-through artifact from the T2-weighted abnormalities. The inhomogeneous appearance of the CSF is due to the inherent sensitivity to macroscopic fluid motion of the type of diffusion-weighted imaging used in this study.