FIG. 2. T2-weighted MR image (2500/84/2) obtained on the day of presentation shows typical areas of subcortical white matter abnormality without cortical involvement (arrows) in patient (case 2) who was conditioned for transplantation with cyclophosphamide and TBI and who presented with confusion and altered mental status 14 d after transplantation. She did not develop seizures. At the time of toxic reaction, she had grade 4 BMT-related TM and a CsA level within the normal therapeutic range. Her baseline blood pressure of 115/85 mm Hg increased to 167/104 mm Hg at the time of toxic reaction and MR imaging