FIG 1. Case 2: 54-year-old man with a GBM.

A, Time course of the R2* values of the GBM and normal white matter. The R2*_T1C values of the GBM are represented by solid squares and its gamma-fitted curve by a thick line; R2*_T1U is represented by solid circles and its gamma-fitted curve a thin line. The R2*_T1C values of normal white matter are represented by solid triangles and its gamma-fitted curve by a dashed line.

B, A stereotactic biopsy was performed before the MR study. A transaxial section of a contrast-enhanced T1-weighted (333/10/3) spin-echo image is shown on the left, the corresponding V_T1U map is in the middle, and the V_T1C map is on the right. The GBM shows nonhomogeneously dense contrast enhancement in the left frontotemporal lobe. Note that blood volume of the tumor is much more prominent on the V_T1C map (arrow) than on the V_T1U map. The qualitative analysis was rated as 1 in this case. The V_T1U/V_T1C ratio is 0.41.