FIG 1. Outline summary of voxel-based morphometry. Spatial normalization fitted each individual brain to a standard template brain in 3D space. Normalized MR images were then segmented into gray matter, white matter, cerebrospinal fluid, and other compartments. The gray matter images were smoothed with a 12-mm, full-width half-maximum isotropic gaussian kernel to use the partial volume effect to create a spectrum of gray matter intensities