FIG 2. Negative correlations between age and regional gray matter volume in healthy volunteers. The SPM of the t statistics (after transformation to a SPM [Z] for this contrast) is displayed in a standard format as a maximum intensity projection viewed from the right-hand side and from the back and the top of the brain. The anatomic space corresponds to the atlas of Talairach and Tournoux (18). Significant reduction of regional gray matter volume is noted in the inferior frontal gyrus, the insular cortex, cingulate gyrus, superior temporal gyrus, precuneus, left dorsolateral prefrontal cortex, right inferior parietal lobule, and orbitofrontal cortex