FIG 2. Images from the case of a 70-year-old man with fragile X premutation.

A and B, Axial view T2-weighted images show symmetrically increased T2 signal intensity in the cerebellum with mildly increased signal intensity in the MCPs.

C, Coronal view T2-weighted image. Moderate cerebellar volume loss and severe parietal cortical volume loss can be seen with thinning of the corpus callosum. Punctate areas of cerebral white matter increased signal intensity.

D, Sagittal view T1-weighted image shows mild pontine volume loss, decreased anteroposterior dimension of the pons, prominence in prepontine cistern, and severe thinning of the corpus callosum.