FIG 3. Images from the case of a 61-year-old man with fragile X premutation.

A and B, Increased signal intensity is shown in inferior cerebellar white matter on inversion recovery images. The deep cerebellar nuclei are normal in size and signal intensity. The pons is normal in signal intensity.

C and D, Axial view T1-weighted images show volume loss involving the pontomesencephalic junction with enlargement of the temporal horns and ambient cisterns. The cerebral peduncles are moderately decreased in area (D). Moderate enlargement of the lateral ventricles and cerebral sulci can be seen.

E, Axial view inversion recovery image shows increased signal intensity in the thinned corpus callosum and in periventricular white matter.