FIG 4. Images from the case of a 69-year-old man with fragile X premutation.

A and B, Axial view T2-weighted images show increased signal intensity in the MCPs, which are slightly thinned in the oblique transverse dimension. Prominence in size of the subarachnoid spaces can be seen. The pons shows a nonspecific right paramedian punctate area of increased signal intensity.

C, Axial view T2-weighted image. Mesencephalon and middle cerebral peduncles are mildly decreased in size, with prominence of the ambient cisterns.

D, Axial view inversion recovery image shows volume loss with increased signal intensity in frontal and parietal white matter and in the genu of the thinned corpus callosum.

E, Coronal view T2-weighted image shows volume loss and increased T2 signal intensity in the frontal white matter and in the thinned corpus callosum.