FIG 3. Comparison of patient and control spectra in the frontal lobe subcortical white matter in the group aged older than 2 years.

A, Proton MR spectrum in a 5-year-old patient with mild developmental delay in language and coordination demonstrates marked increase in the Cho/Cr ratio to 1.79. There is a decrease in the NAA/Cr ratio to 2.06, which resembles the MR spectrum of a much younger child such as seen in the 1.5-year-old children in Fig 2.

B, Proton MR spectrum in a 5-year-old control patient demonstrates a pattern resembling that of an adult, with an NAA peak that is 2 times higher than the Cr peak and a Cho peak that is slightly elevated compared with the Cr peak. The NAA/Cr ratio of 2.50 and Cho/Cr ratio of 1.42 are normal.