FIG 2. LS non SURF-1. Case 8. Female patient, 8 months old at first examination.

A and B, Axial T2-weighted MR images (3000/120/1) obtained at first examination show hyperintense lesions in the substantia nigra (arrow in A) and medial thalamic nuclei (arrowhead in B). The globi pallidi and white matter, still unmyelinated, are slightly hyperintense, with a tiny, focal hyperintensity in the left pallidum.

C, Follow-up MR image (2028/120/2), obtained 2 years and 2 months later, shows lesions in the basal ganglia that involve both the putamina and the head of the left caudate nucleus. A minimal residual right thalamic lesions is visible (arrowhead). Moderate diffuse brain atrophy is present.