FIG 1. Three examples of MS lesions (arrows) with different T1 appearance. Top, isointense lesion (FA=0.30 ± 0.06, coefficient D_av=1.10 ± 0.07 x 10^-3 mm²/s); middle, mildly hypointense lesion (FA=0.27 ± 0.05, coefficient D_av=1.24 ± 0.06 x 10^-3 mm²/s); bottom, severely hypointense lesion (FA=0.19 ± 0.04, coefficient D_av = 1.76 ± 0.07 x 10^-3 mm²/s). For each row, from left to right: axial view fast spin-echo T2-weighted image, spin-echo T1-weighted image, coefficient D_av map, and FA map.