FIG 5. Parametric images of distribution of rCBV and TTP (A and B) and rR and TTP (C and D) in a patient presenting with expressive dysphasia and an established left-sided cortical laminar stroke (case 1). Angiogram shows advanced steno-occlusive changes in the left internal carotid artery (see Fig 1, internal carotid artery grade IV) with associated moyamoya changes. Color coding is as described in the legend to Figure 3; Color charts explain color coding for each image type. Areas of increased TTP and rR (E and F) where rCBV is >50%. Note the presence of abnormal areas of neovasculature around the middle cerebral arteries, indicated by prolonged TTP, high rCBV, and abnormal prolongation of rR. The presence of neovascularization was confirmed on digital subtraction angiograms (Fig 1). Extensive areas of prolonged TTP can be seen throughout both hemispheres. Abnormal values of rR are seen in the central portions of these areas (yellow on E and F). The rCBV in these areas is low in distinction to the areas of prolonged rR seen in areas of neovascularization.