FIG 4. Patient 1. Serial DW images (A–C) and corresponding ADC maps (D–F) acquired 3 (A and D), 4 (B and E), and 8 (C and F) months after onset of symptoms. The DW image acquired 3 months after onset of symptoms (A) shows bilateral high SI in the caudate nucleus and the rostral part of the putamen. Four months after onset of symptoms, the DW image (B) shows high SI also in the dorsal part of the putamen and additionally in the pulvinar thalami. Eight months after onset of symptoms, the DW image (C) shows severe brain atrophy with widening of the ventricles and of the sulci. The head of the caudate nucleus on the left side totally disappeared; the right caudate nucleus and the putamen on both sides show severe atrophy. There is high SI in the right caudate nucleus and putamen bilaterally and in the frontal, parietal, and cingulate cortex. The ADC maps (D–F) show low SI in the hyperintense areas on DW images corresponding to restricted diffusion.