FIG 5. Patient 1. Time courses of the ADC values in serial images. Measurements were performed in five anatomic regions: the head of the caudate nucleus (empty rectangle), the putamen (open rhomboid), the pulvinar thalami (filled triangle), the MD (filled circle), and the hippocampus (star). In all areas except for the hippocampus, ADCs were lowest in the first examination and highest in the last examination. In the caudate nucleus, the putamen, and the MD, there was a gradual increase in the ADCs during the course of the disease. In the pulvinar thalami, ADCs were lowest in the second examination; this was paralleled by an increased SI on DW images in the second examination (shown in Fig 4B, E).