FIG 5. Other MR imaging findings in vCJD.

A, Axial FLAIR image shows periaqueductal gray matter hyperintensity (arrow). Though not a specific sign, periaqueductal gray matter hyperintensity was seen in 83% of cases with FLAIR imaging.

B, FLAIR image shows abnormal hyperintensity in the centrum semiovale white matter (arrows), reflecting the diffuse involvement of the brain by the disease.

C, FLAIR image shows asymmetrical bilateral pulvinar hyperintensity. Asymmetrical hyperintensity was a rare finding in vCJD, seen in less than 5% of cases.

D, PD-weighted image shows widespread basal ganglia hyperintensity. Though hyperintensity in the basal ganglia is also seen in a number of other conditions, the signal intensity of the pulvinar remains the most hyperintense, helping to categorize this case correctly as probable vCJD.

E and F, Case of progressive cerebral atrophy in vCJD. Two images taken 3 months apart show subtle but definite global cerebral atrophy. Unlike in sCJD, cerebral atrophy is not a prominent feature of vCJD and is most easily seen in the parietooccipital region.