FIG 1. Coronal photomicrographs of normal and atrophic hippocampus (Klüver-Barrera stain).

A, Image in a 56-year-old man with dentatorubro-pallidoluysian atrophy shows no atrophy of the left subiculum or hippocampus proper. Image represents a normal hippocampus. The hippocampus proper consists of the CA1, CA2, CA3, and CA4 fields. Bar indicates 1 mm.

B, Image in a 78-year-old man with AD (duration of illness, 15 years) shows severe atrophy of the subiculum (arrow). The superficial medullary lamina (arrowheads) is thinner than that of a normal hippocampus. Bar indicates 1 mm.

C, Magnified (x200) view of the image in A shows numerous nerve fibers running in the anteroposterior direction in the superficial medullary lamina of the hippocampal formation.