FIG 6. Scatterplots of BPF versus third ventricular width in patients with MS (n = 52), showing 2D semiautomated (A), 3D semiautomated (B), and 3D automated (C) BPFs. The semiautomated and automated 3D BPFs showed similarly robust inverse correlations with third ventricular width, which indicates a relationship between whole-brain atrophy and central brain atrophy.