FIG 7. Scatterplots of BPF versus bicaudate ratio in patients with MS (n = 52), showing 2D semiautomated (A), 3D semiautomated (B), and 3D automated (C) BPFs. The semiautomated and automated BPFs showed identically robust inverse correlations with bicaudate ratio, which indicates an association between whole-brain atrophy and subcortical brain atrophy.