FIG 8. Scatterplots of BPF versus total brain T1-hypointense lesion volume in patients with MS (n = 52), showing 2D semiautomated (A), 3D semiautomated (B), and 3D automated (C) BPFs. The semiautomated and automated BPFs showed similarly moderate inverse correlations with T1-hypointense lesion volume.