FIG 1. Statistical mapping analysis. Patterns of significant MTR abnormalities are observed inside the corpus callosum, bilateral occipitofrontal fascicles, right fornix, right parietal white matter, external capsule, right SLF, right ILF, optica radiata, parietal white matter, right cingulum, bilateral thalamus, bilateral caudate, right insula, and the left BA8.

A, Multiplanar images of MTR decrease observed in patients with CISSMS compared with control subjects.

B, Transverse images of MTR decrease observed in patients with CISSMS compared with control subjects.