FIG 9. Scatterplots of ADC values and anisotropy index versus axonal dieback

A and B, Scatterplots of tADC and lADC versus percentage axonal dieback show that as axonal loss increases closer to the injury site, tADC increases and lADC decreases.

C, Scatterplot of anisotropy index (tADC/lADC ratio) versus percentage axonal dieback shows that the changes in ADC values seen with increasing axonal loss produce an increasing anisotropy index, indicating decreasing anisotropic water diffusion.