FIG 5. A 36-year-old woman with PCNSL (patient 4 in Table 1). Appearance of new T2 signal intensity abnormality. Baseline Z score –2.03; end-of-treatment Z score –.79.

A, B, Baseline axial T2-weighted images demonstrate no signal intensity abnormality in the periventricular white matter and centrum semiovale.

C, D, End-of-treatment axial T2-weighted images show diffuse high signal intensity in the periventricular white matter and centrum semiovale bilaterally (arrows).