FIG 5. A and B, Conventional MR images (A) and Z score images (B) obtained in a 54-year-old patient with early-onset AD (MMSE score = 23). Mild right parietal lobular atrophy can be detected by visual inspection of the conventional T1-weighted images; however, the degree of atrophy was not estimated. By using the Z score map, the region and degree of atrophy can be detected easily, enabling this case to be diagnosed as AD. Areas with Z scores greater than 2 (indicated by rainbow color scale) in this subject were overlaid on the prototypic early-onset AD template map (overlaid on normal MR images with red area). L indicates left; R, right.