FIG 1. Cryptococcal meningitis.

A, Contrast-enhanced FLAIR image shows slight leptomeningeal enhancement in the right frontoparietal region (arrows). It is difficult to separate meningeal enhancement from other high signal intensity within the sulci and from adjacent parenchymal disease.

B, Contrast-enhanced T1-weighted image with FS shows greater contrast between the enhancing tissue and the adjacent brain and is better for depicting enhancement within the sulci and the interhemispheric fissure (arrows).

C, Contrast-enhanced FLAIR image of the same patient obtained at the level of the sylvian fissures shows subtle enhancing lesions in the basal ganglia bilaterally, but without a noncontrast FLAIR image for comparison it is not possible to distinguish enhancement from parenchymal edema.

D, Contrast-enhanced T1-weighted image with FS shows multiple punctuate enhancing areas within the basal ganglia bilaterally, due to cryptococcomas within dilated Virchow-Robin spaces (arrows). The enhancement is much more conspicuous on the T1-weighted image. Additional enhancement is present in several inferior sulci in both frontal lobes.