FIG 1. Anaplastic astrocytoma. Axial enhanced T1–weighted image demonstrates a right frontal, nonenhancing lesion (A). rCBV map shows a markedly elevated rCBV of 3.6, which is consistent with biopsy-proved anaplastic astrocytoma (B). Immunohistochemical staining (400x) with monoclonal antibody against VEGF reveals strong cellular and endothelial positivity (C).