FIG 4. Anaplastic astrocytoma. Coronal enhanced T1-weighted image shows a heterogeneous left frontal lesion (A). rCBV map demonstrates a focal area with a high rCBV of 3.11. Histologic section (400X) of this focus is consistent with biopsy-proved anaplastic astrocytoma, and VEGF staining shows strong cellular and endothelial positivity (C).