FIG 2. Patient 1, with ADEM. Axial T1-weighted images without (A) and with (B) gadolinium (inset coronal) show faint, subtle enhancement in multiple brain stem lesions. Six days later (C) significant, more prominent, larger ferumoxtran-10 enhancement can be seen on the same site (inset, coronal). Three months later (D) the lesions no longer enhance on T1-weighted images with gadolinium.