Fig 1. Ultra-small-particle iron oxide (USPIO)- and gadolinium-enhanced multiple sclerosis (MS) lesions on several MR imaging sequences. MR imaging 1 performed with fluid-attenuated inversion recovery (FLAIR) (A), T2-weighted (B), T2*-weighted (C), and magnetization transfer T1-weighted postgadolinium images (D). Some MS lesions were enhanced by gadolinium. MR imaging 2, performed 24 hours after USPIO injection, shows an uptake of USPIO in 1 lesion on FLAIR (E), turbo spin echo (TSE) T2-weighted (F), T2*-weighted (G), and T1-weighted (H) images (short arrows). Veins are clearly seen as dark signal intensity on T2*-weighted images (G) (long arrow).