Fig 2. Receiver operating characteristic (ROC) curve for diagnostic model using fractional anisotropy (FA)_mean, FA_ant,right, and FA_central (model 1, solid line in 2A and 2B, area under ROC curve (AUC), 0.928; 95% confidence interval [CI], 0.813 to 0.982), showing a significantly higher AUC compared with a model using only FA_mean (2A, thick dotted line, difference between AUCs = 0.180, P = .012) as well as a model using only FA_central (2B, thick dotted line, difference between AUCs = 0.274, P = .001). In other words, the best performing test is one in which multiple ROIs provide spatial information.