Fig 4. Thrombolysis achieved partial restoration of cerebral perfusion in 1 animal.

A, Pretreatment time to peak of a single coronal section demonstrates a large region of prolonged TTP in the left MCA territory (arrows).

B, The ADC image acquired at 2 hours confirms a region of reduced ADC.

C, The corresponding TTP acquired upon completion of the infusion of rtPA shows marked improvement of flow in the affected territory. Quantitative flow images calculated before (D) and after (E) treatment show that qCBF in the region affected by the stroke has been restored to a value that is above the known threshold for ischemic stroke.