Fig 3. High-grade glioma, glioblastoma multiforme (grade IV/IV) in frontal lobes spanning the corpus callosum. T2-weighted (A) and contrast T1-weighted (B) images are shown along with rCBVmax map (C) with ROIs targeted to avoid areas of radiologic necrosis to determine perfusion curves (E). rCBV histogram map (D) and histogram curve (F) are derived from the maximal tumor diameter regardless of heterogeneity.