Fig 2. MR imaging scans of a 57-year-old patient with probable sporadic CJD 8 months after onset of disease. On DW MR imaging (A, C, E), there is hyperintensity in the striatum and insula (A), the superior and middle frontal gyri, and the precuneus (C), the superior and middle frontal gyri, the precuneus, and the paracentral lobe (E). On FLAIR (B, D), the insula and cingulate gyrus show increased signal intensity, whereas the hyperintense changes in the precuneus and paracentral lobe, easily identified on DW imaging (E), are questionable on FLAIR (F).