Fig 3. DW (A, B) and FLAIR (C, D) MR imaging of a 63-year-old patient with definite sporadic CJD after 4 months of disease. There is extensive signal hyperintensity, including the cingulate gyrus (A–D), the frontal superior gyrus (A–D), occipital gyrus (A, C), the insula (A, C), the temporal medial gyrus (A, C), and the angular/supramarginal gyrus (B, D). The basal ganglia have normal signal intensity (A, C). The changes in signal intensity are easier to identify on DW (A, B) than on FLAIR imaging (C, D). (Images courtesy of H. Zeumer, Department of Neuroradiology, University Hospital Hamburg-Eppendorf, Germany.)