Fig 1. A, Axial T2-weighted and coronal and sagittal T1-weighted MR images from a healthy control, demonstrating the positioning of the voxel (white frame) within the NAWM.
B, 1H-MR spectroscopy spectrum from a healthy control (upper row), a patient with CIS (middle row), and a patient with MS (bottom row). Note the decreased concentrations of tNAA in both patients and increased concentrations of mIns, particularly in the MS patient when compared with the age-matched healthy control (arrows). CIS indicates clinically isolated syndrome; MS, multiple sclerosis; tNAA, summation of N-acetylaspartate and N-acetylaspartyl-glutamate; mIns, myo-inositol; Cho, choline; tCr, summation of creatine and phosphor-creatine; Glx, summation of glutamate and glutamine.