Fig 3. HCC: intermediate and chronic stages (patient 7). A, Axial T1-weighted image (437/16/2, TR/TE/NEX) obtained at 8 years of age shows hypointense deep and periventricular white matter, with an anterior-to-posterior gradient of severity. B, Axial T2-weighted image (4000/96/2, TR/TE/NEX) obtained at 8 years of age shows marked white matter hyperintensity, paralleling that of CSF and prevailing in the frontal regions. C, Axial DWI obtained at 15 years of age shows shrunken white matter with markedly increased diffusivity. The ADC value in deep frontal white matter was 2.094 mm²/s. D, Axial T2-weighted image (4157/100/2, TR/TE/NEX) confirms shrinkage of affected white matter (compare with B).