Fig 3. Brain injury results in activation of TGF-β responsive genes and the Smad-binding element (SBE)-firefly luciferase (luc) reporter. Two SBE-luc mice with similar basal levels of bioluminescence were lesioned with a needle stab to the right hemisphere or were left untreated (control), and bioluminescence was recorded 1 hour later. To highlight the increase in signal intensity in the lesioned mouse, the color scale was adjusted to leave the basal Fluc expression in the control mouse uncolored (<200 photons[p]/s/mm²/sr). (Copyright 2005, The American Association of Immunologists)