Fig 3. Mean ADC values. The cohort is divided in 3 groups: NF-1 regions with UBOs (UBO), NF-1 regions with normal-appearing brain matter (NAS), and controls. Mean ADC values for UBOs are higher than those for NAS in all regions (except POWM and FWM where no UBOs were found). Mean ADC values for NAS are significantly higher than those of controls in all regions, except CP. For convenience, the results of the HI area are presented in the same figure as the results of the other regions of interest. HI hyperintensities are presented as UBOs and normal-appearing HI areas as NAS. Significant differences between UBO and NAS are indicated by and between NAS and controls by .