Fig 1. Hippocampal volume in patients with MCI versus controls. Hippocampal volume is calculated as the total volume of the right and left hippocampus and regressed on ICV. The standardized residuals are shown on the y-axis (z-scores). The patients are grouped according to whether they have pathologic (MCI pat CSF) or nonpathologic (MCI no CSF) values of tau or Aβ42. The blue-dotted lines indicate the mean value for each group. Independent samples t tests (Bonferroni corrected for multiple comparisons) showed that the patients with pathologic CSF biomarkers had significantly smaller hippocampal volume than the controls, whereas the other contrasts did not reach significance.