Fig 2. Regional cortical gray matter volume increase (orange/red) and reduction (blue) in patients with KS without MM relative to control subjects. Significant voxels (height threshold of P < .001, uncorrected for multiple comparisons and an extent threshold of 25 voxels) are superimposed on selected sections of spatially normalized MR images from a control subject. With the hypothesis a priori, areas of increased gray matter are seen in the left frontal lobe, Brodmann area 6 (the cluster with 304 voxels), and in the right precentral gyrus, contralateral area 4 (the cluster with 27 voxels).