American Journal of Neuroradiology, Vol 11, Issue 3 423-429, Copyright © 1990 by American Society of Neuroradiology
ARTICLES |
Diffusion-weighted MR imaging of acute stroke: correlation with T2- weighted and magnetic susceptibility-enhanced MR imaging in cats
ME Moseley, J Kucharczyk, J Mintorovitch, Y Cohen, J Kurhanewicz, N Derugin, H Asgari and D Norman
Department of Radiology, University of California, San Francisco 94143.
We evaluated the temporal and anatomic relationships between changes in diffusion-weighted MR image signal intensity, induced by unilateral occlusion of the middle cerebral artery in cats, and tissue perfusion deficits observed in the same animals on T2-weighted MR images after administration of a nonionic intravascular T2 shortening agent. Diffusion-weighted images obtained with strong diffusion-sensitizing gradient strengths (5.6 gauss/cm, corresponding to gradient attenuation factor, b, values of 1413 sec/mm2) displayed increased signal intensity in the ischemic middle cerebral artery territory less than 1 hr after occlusion, whereas T2-weighted images without contrast usually failed to detect injury for 2-3 hr after stroke. After contrast administration (0.5-1.0 mmol/kg by Dy-DTPA-BMA, IV), however, T2-weighted images revealed perfusion deficits (relative hyperintensity) within 1 hr after middle cerebral artery occlusion that corresponded closely to the anatomic regions of ischemic injury shown on diffusion-weighted MR images. Close correlations were also found between early increases in diffusion-weighted MR image signal intensity and disrupted phosphorus- 31 and proton metabolite levels evaluated with surface coil MR spectroscopy, as well as with postmortem histopathology. These data indicate that diffusion-weighted MR images more accurately reflect early-onset pathophysiologic changes induced by acute cerebral ischemia than do T2-weighted spin-echo images.
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R. L. Robertson, S. E. Maier, R. V. Mulkern, S. Vajapayam, C. D. Robson, and P. D. Barnes MR Line-scan Diffusion Imaging of the Spinal Cord in Children AJNR Am. J. Neuroradiol., July 1, 2000; 21(7): 1344 - 1348. [Abstract] [Full Text] [PDF]
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K. H. Lee, S.-J. Cho, H. S. Byun, D. G. Na, N.-C. Choi, S. J. Lee, I.-S. Jin, T. G. Lee, and C.-S. Chung Triphasic Perfusion Computed Tomography in Acute Middle Cerebral Artery Stroke: A Correlation With Angiographic Findings Arch Neurol, July 1, 2000; 57(7): 990 - 999. [Abstract] [Full Text] [PDF]
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J. Oliveira-Filho, H. Ay, P. W. Schaefer, F. S. Buonanno, Y. Chang, R. G. Gonzalez, and W. J. Koroshetz Diffusion-Weighted Magnetic Resonance Imaging Identifies the "Clinically Relevant" Small-Penetrator Infarcts Arch Neurol, July 1, 2000; 57(7): 1009 - 1014. [Abstract] [Full Text] [PDF]
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S. Roychowdhury, J. A. Maldjian, and R. I. Grossman Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions AJNR Am. J. Neuroradiol., May 1, 2000; 21(5): 869 - 874. [Abstract] [Full Text]
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L. J. Lee, C. S. Kidwell, J. Alger, S. Starkman, and J. L. Saver Impact on Stroke Subtype Diagnosis of Early Diffusion-Weighted Magnetic Resonance Imaging and Magnetic Resonance Angiography Stroke, May 1, 2000; 31(5): 1081 - 1089. [Abstract] [Full Text] [PDF]
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C. J. Chaves, B. Silver, G. Schlaug, J. Dashe, L. R. Caplan, and S. Warach Diffusion- and Perfusion-Weighted MRI Patterns in Borderzone Infarcts Stroke, May 1, 2000; 31(5): 1090 - 1096. [Abstract] [Full Text] [PDF]
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F. Li, K.-F. Liu, M. D. Silva, T. Omae, C. H. Sotak, J. D. Fenstermacher, M. Fisher, C. Y. Hsu, and W. Lin Transient and Permanent Resolution of Ischemic Lesions on Diffusion-Weighted Imaging After Brief Periods of Focal Ischemia in Rats : Correlation With Histopathology • Editorial Comment: Correlation With Histopathology Stroke, April 1, 2000; 31(4): 946 - 954. [Abstract] [Full Text] [PDF]
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N. Miyasaka, T. Kuroiwa, F. Y. Zhao, T. Nagaoka, H. Akimoto, I. Yamada, T. Kubota, and T. Aso Cerebral Ischemic Hypoxia: Discrepancy between Apparent Diffusion Coefficients and Histologic Changes in Rats Radiology, April 1, 2000; 215(1): 199 - 204. [Abstract] [Full Text]
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A. E. Baird, K. O. Lovblad, G. Schlaug, R. R. Edelman, and S. Warach Multiple acute stroke syndrome: Marker of embolic disease? Neurology, February 8, 2000; 54(3): 674 - 674. [Abstract] [Full Text] [PDF]
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F. Li, M. D. Silva, C. H. Sotak, and M. Fisher Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI Neurology, February 8, 2000; 54(3): 689 - 689. [Abstract] [Full Text] [PDF]
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S. Terai, T. Hori, S. Miake, K. Tamaki, and A. Saishoji Mechanism in Progressive Lacunar Infarction: A Case Report With Magnetic Resonance Imaging Arch Neurol, February 1, 2000; 57(2): 255 - 258. [Abstract] [Full Text] [PDF]
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R. I. Grossman BRAIN IMAGING AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 9 - 18. [Full Text] [PDF]
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M. Muller, W. Reiche, P. Langenscheidt, J. Ha{beta}feld, and T. Hagen Ischemia after Carotid Endarterectomy: Comparison between Transcranial Doppler Sonography and Diffusion-Weighted MR Imaging AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 47 - 54. [Abstract] [Full Text] [PDF]
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N. Miyasaka, T. Nagaoka, T. Kuroiwa, H. Akimoto, T. Haku, T. Kubota, and T. Aso Histopathologic Correlates of Temporal Diffusion Changes in a Rat Model of Cerebral Hypoxia/Ischemia AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 60 - 66. [Abstract] [Full Text] [PDF]
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D. Lefkowitz, M. LaBenz, S. R. Nudo, R. E. Steg, and J. M. Bertoni Hyperacute Ischemic Stroke Missed by Diffusion-Weighted Imaging AJNR Am. J. Neuroradiol., November 1, 1999; 20(10): 1871 - 1875. [Abstract] [Full Text]
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Q. Yang, B. M. Tress, P. A. Barber, P. M. Desmond, D. G. Darby, R. P. Gerraty, T. Li, and S. M. Davis Serial Study of Apparent Diffusion Coefficient and Anisotropy in Patients With Acute Stroke Stroke, November 1, 1999; 30(11): 2382 - 2390. [Abstract] [Full Text] [PDF]
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 M. van Lookeren Campagne, H. Thibodeaux, N. van Bruggen, B. Cairns, R. Gerlai, J. T. Palmer, S. P. Williams, and D. G. Lowe Evidence for a protective role of metallothionein-1 in focal cerebral ischemia PNAS, October 26, 1999; 96(22): 12870 - 12875. [Abstract] [Full Text] [PDF]
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R. L. Robertson, L. Ben-Sira, P. D. Barnes, R. V. Mulkern, C. D. Robson, S. E. Maier, M. J. Rivkin, and A. J. d. Plessis MR Line-Scan Diffusion-Weighted Imaging of Term Neonates with Perinatal Brain Ischemia AJNR Am. J. Neuroradiol., October 1, 1999; 20(9): 1658 - 1670. [Abstract] [Full Text]
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K. R. Thulborn, T. S. Gindin, D. Davis, and P. Erb Comprehensive MR Imaging Protocol for Stroke Management: Tissue Sodium Concentration as a Measure of Tissue Viability in Nonhuman Primate Studies and in Clinical Studies Radiology, October 1, 1999; 213(1): 156 - 166. [Abstract] [Full Text]
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D. G. Darby, P. A. Barber, R. P. Gerraty, P. M. Desmond, Q. Yang, M. Parsons, T. Li, B. M. Tress, and S. M. Davis Pathophysiological Topography of Acute Ischemia by Combined Diffusion-Weighted and Perfusion MRI Stroke, October 1, 1999; 30(10): 2043 - 2052. [Abstract] [Full Text] [PDF]
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P. A. Barber, D. G. Darby, P. M. Desmond, R. P. Gerraty, Q. Yang, T. Li, D. Jolley, G. A. Donnan, B. M. Tress, and S. M. Davis Identification of Major Ischemic Change : Diffusion-Weighted Imaging Versus Computed Tomography Stroke, October 1, 1999; 30(10): 2059 - 2065. [Abstract] [Full Text] [PDF]
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A. J. de Crespigny, J. Rother, C. Beaulieu, M. E. Moseley, and M. Hoehn Rapid Monitoring of Diffusion, DC Potential, and Blood Oxygenation Changes During Global Ischemia : Effects of Hypoglycemia, Hyperglycemia, and TTX • Editorial Comment: Effects of Hypoglycemia, Hyperglycemia, and TTX Stroke, October 1, 1999; 30(10): 2212 - 2222. [Abstract] [Full Text] [PDF]
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G. W. Albers Expanding the Window for Thrombolytic Therapy in Acute Stroke : The Potential Role of Acute MRI for Patient Selection Stroke, October 1, 1999; 30(10): 2230 - 2237. [Abstract] [Full Text] [PDF]
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P. E. Ricci, J. H. Burdette, A. D. Elster, and D. M. Reboussin A Comparison of Fast Spin-Echo, Fluid-Attenuated Inversion-Recovery, and Diffusion-Weighted MR Imaging in the First 10 Days after Cerebral Infarction AJNR Am. J. Neuroradiol., September 1, 1999; 20(8): 1535 - 1542. [Abstract] [Full Text]
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J. M. Provenzale Nontraumatic Neurologic Emergencies: Imaging Findings and Diagnostic Pitfalls RadioGraphics, September 1, 1999; 19(5): 1323 - 1331. [Full Text] [PDF]
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J. L. Sunshine, R. W. Tarr, C. F. Lanzieri, D. M. D. Landis, W. R. Selman, and J. S. Lewin Hyperacute Stroke: Ultrafast MR Imaging to Triage Patients prior to Therapy Radiology, August 1, 1999; 212(2): 325 - 332. [Abstract] [Full Text]
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J. H. Burdette, A. D. Elster, and P. E. Ricci Acute Cerebral Infarction: Quantification of Spin-Density and T2 Shine-through Phenomena on Diffusion-weighted MR Images Radiology, August 1, 1999; 212(2): 333 - 339. [Abstract] [Full Text]
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J. O. Karonen, R. L. Vanninen, Y. Liu, L. Ostergaard, J. T. Kuikka, J. Nuutinen, E. J. Vanninen, P. L. K. Partanen, P. A. Vainio, K. Korhonen, et al. Combined Diffusion and Perfusion MRI With Correlation to Single-Photon Emission CT in Acute Ischemic Stroke : Ischemic Penumbra Predicts Infarct Growth Stroke, August 1, 1999; 30(8): 1583 - 1590. [Abstract] [Full Text] [PDF]
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