AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roman-Goldstein, S. M.
Right arrow Articles by Neuwelt, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roman-Goldstein, S. M.
Right arrow Articles by Neuwelt, E. A.

American Journal of Neuroradiology, Vol 13, Issue 4 1207-1213, Copyright © 1992 by American Society of Neuroradiology

ARTICLES

MR of primary CNS lymphoma in immunologically normal patients

SM Roman-Goldstein, DL Goldman, J Howieson, R Belkin and EA Neuwelt
Department of Diagnostic Radiology, Oregon Health Sciences University, Portland 97201-3098.

PURPOSE: To describe the MR findings of primary CNS lymphoma. METHODS: MR scans of 20 patients with histologically proved primary CNS lymphoma were reviewed. We evaluated the size, multiplicity, signal intensities, and enhancement characteristics of the lesions. We divided the lesions into an enhancing area referred to as Zone 1 and abnormal signal surrounding this, referred to as Zone 2. RESULTS: Primary CNS lymphoma presented as solitary enhancing lesions in 40% of the patients and multiple lesions in 40%. Thirty-three separate lesions were visible: 58% abutted the ventricular system, 76% showed a homogenous enhancement pattern, and 79% showed marked enhancement. In 64% of the lesions, Zone 1 and Zone 2 showed different signal intensities on T1-weighted images. CONCLUSIONS: Primary CNS lymphoma usually presents as solitary or multiple dense homogenous enhancing lesions that abut an ependymal surface. These lesions can be divided into an enhancing area and an area of surrounding abnormal signal. These two areas often have different signal intensities on unenhanced T2-weighted images. These findings are sufficiently suggestive of the diagnosis of primary CNS lymphoma that a needle biopsy be performed based on these findings and appropriate therapy can then be instituted.


This article has been cited by other articles:


Home page
 Neuro Oncol DukeHome page
K. Jahnke, L. L. Muldoon, C. G. Varallyay, S. J. Lewin, R. D. Brown, D. F. Kraemer, C. Soussain, and E. A. Neuwelt
Efficacy and MRI of rituximab and methotrexate treatment in a nude rat model of CNS lymphoma
Neuro-oncol, January 1, 2009; 11(5): 503 - 513.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Soussain, L. L. Muldoon, C. Varallyay, K. Jahnke, L. DePaula, and E. A. Neuwelt
Characterization and Magnetic Resonance Imaging of a Rat Model of Human B-Cell Central Nervous System Lymphoma
Clin. Cancer Res., April 15, 2007; 13(8): 2504 - 2511.
[Abstract] [Full Text] [PDF]

Home page
 Neuro Oncol DukeHome page
P. Kiewe, C. Loddenkemper, I. Anagnostopoulos, M. Reinwald, E. Thiel, and A. Korfel
High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma
Neuro-oncol, April 1, 2007; 9(2): 96 - 102.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K. Jahnke, A. Schilling, J. Heidenreich, H. Stein, M. Brock, E. Thiel, and A. Korfel
Radiologic Morphology of Low-Grade Primary Central Nervous System Lymphoma in Immunocompetent Patients
AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2446 - 2454.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. Kuker, T. Nagele, E. Thiel, M. Weller, and U. Herrlinger
Primary central nervous system lymphomas (PCNSL): MRI response criteria revised
Neurology, October 11, 2005; 65(7): 1129 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. A. Neuwelt, P. E. Guastadisegni, P. Varallyay, and N. D. Doolittle
Imaging Changes and Cognitive Outcome in Primary CNS Lymphoma after Enhanced Chemotherapy Delivery
AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 258 - 265.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
T. T. Batchelor, B. R. Buchbinder, and N. L. Harris
Case 1-2005 - A 35-Year-Old Woman with Difficulty Walking, Headache, and Nausea
N. Engl. J. Med., January 13, 2005; 352(2): 185 - 194.
[Full Text] [PDF]

Home page
 RadioGraphicsHome page
T. W. Stadnik, P. Demaerel, R. R Luypaert, C. Chaskis, K. L. Van Rompaey, A. Michotte, and M. J. Osteaux
Imaging Tutorial: Differential Diagnosis of Bright Lesions on Diffusion-weighted MR Images
RadioGraphics, January 1, 2003; 23(1): e7 - e7.
[Abstract] [Full Text]

Home page
 NeurologyHome page
U. Buhring, U. Herrlinger, T. Krings, R. Thiex, M. Weller, and W. Kuker
MRI features of primary central nervous system lymphomas at presentation
Neurology, August 14, 2001; 57(3): 393 - 396.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L Ayuso-Peralta, M Orti-Pareja, M Zurdo-Hernandez, F J Jimenez-Jimenez, J Tejeiro-Martinez, J R Ricoy, A de la Lama, and A I Bernardo
Cerebral lymphoma presenting as a leukoencephalopathy
J. Neurol. Neurosurg. Psychiatry, August 1, 2001; 71(2): 243 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
N. Erdag, R. M. Bhorade, R. A. Alberico, N. Yousuf, and M. R. Patel
Primary Lymphoma of the Central Nervous System: Typical and Atypical CT and MR Imaging Appearances
Am. J. Roentgenol., May 1, 2001; 176(5): 1319 - 1326.
[Full Text] [PDF]

Home page
 Neuro Oncol DukeHome page
T. G. Phan, B. P. O'Neill, and P. J. Kurtin
Posttransplant primary CNS lymphoma
Neuro-oncol, October 1, 2000; 2(4): 229 - 238.
[Abstract] [PDF]


Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X