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American Journal of Neuroradiology, Vol 14, Issue 4 1014-1016, Copyright © 1993 by American Society of Neuroradiology


ARTICLES

High-dose cytarabine neurotoxicity: MR findings during the acute phase

DJ Vaughn, JG Jarvik, D Hackney, S Peters and EA Stadtmauer
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.

The authors report an acute cerebral and cerebellar syndrome in a patient treated with high-dose cytarabine. Diffuse high-intensity lesions in the central white matter on T2-weighted MR completely reversed with resolution of the clinical syndrome. Although the autopsy revealed cerebellar injury, the cerebral cortex was grossly and microscopically normal, consistent with a reversible process.


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