American Journal of Neuroradiology, Vol 16, Issue 10 2021-2027, Copyright © 1995 by American Society of Neuroradiology
ARTICLES |
Cranial MR in Wilson disease: abnormal white matter in extrapyramidal and pyramidal tracts
HN van Wassenaer-van Hall, AG van den Heuvel, GH Jansen, TU Hoogenraad and WP Mali
Department of Radiology, University Hospital Utrecht, The Netherlands.
PURPOSE: To describe abnormal white matter in the brain on MR in Wilson disease and to compare with anatomic location of white matter tracts. METHODS: Forty-six patients with Wilson disease were examined. Axial T1- weighted inversion-recovery, axial T2-weighted spin-echo, and coronal T2*-weighted gradient-echo MR images were performed. Imaging studies were compared with clinical data. RESULTS: Seventeen patients showed abnormalities in the region coinciding with the following white matter tracts: corticospinal tract (24%, n = 11), dentatorubrothalamic tract (24%, n = 11), and pontocerebellar tract (17%, n = 8). CONCLUSION: Abnormal extrapyramidal and pyramidal white matter tracts are part of the neuroimaging spectrum of Wilson disease. No significant correlation was found with neurologic groups and individual white matter tracts affected.
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