American Journal of Neuroradiology, Vol 16, Issue 2 225-231, Copyright © 1995 by American Society of Neuroradiology
ARTICLES |
Lysolecithin-induced demyelination in primates: preliminary in vivo study with MR and magnetization transfer
V Dousset, B Brochet, A Vital, C Gross, A Benazzouz, A Boullerne, AM Bidabe, AM Gin and JM Caille
Department of Neuroradiology, Hospital Pellegrin, University of Bordeaux II, France.
PURPOSE: To study bystander demyelination in multiple sclerosis with an experimental in vivo model of toxic demyelination. METHODS: Toxic demyelinating lesions were created in two monkeys by injection of lysophosphatidylcholine in the centrum semiovale. Follow-up was done clinically and with serial MR studies, including T2-weighted and gadolinium-enhanced T1-weighted images and measurement of magnetization transfer ratio, until the animals were killed at days 14 and 34, respectively. Light and electron microscopy analysis was compared with MR data. RESULTS: Interval measurement of magnetization transfer ratio during the course of the experiment revealed a maximum decrease at day 7 to day 8, associated with the greatest clinical manifestations. The lowest values of magnetization transfer ratio correlated with histopathologic findings of myelin and axon destruction. Magnetization transfer ratio measurements appear to be sensitive to macromolecular destruction and specifically to membrane disorganization. At no time was gadolinium enhancement observed in this model of toxic demyelination. CONCLUSION: Preliminary results of this study indicated that magnetization transfer is a good technique to follow in vivo matrix destruction in brain parenchyma lesions. The results suggest also that phases of toxic demyelination in multiple sclerosis might not show gadolinium enhancement. Differentiation between demyelinating activity and associated inflammation in multiple sclerosis lesions should be considered in further in vivo work.
This article has been cited by other articles:
 |
|
 |
|
  V. E. Miron, S. P. Zehntner, T. Kuhlmann, S. K. Ludwin, T. Owens, T. E. Kennedy, B. J. Bedell, and J. P. Antel Statin Therapy Inhibits Remyelination in the Central Nervous System Am. J. Pathol., May 1, 2009; 174(5): 1880 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rovira, J. Alonso, and J. Cordoba MR Imaging Findings in Hepatic Encephalopathy AJNR Am. J. Neuroradiol., October 1, 2008; 29(9): 1612 - 1621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wu, P. Storey, A. Carrillo, C. Saglamer, B.A. Cohen, L.G. Epstein, R.R. Edelman, and A.B. Ragin Whole Brain and Localized Magnetization Transfer Measurements Are Associated with Cognitive Impairment in Patients Infected with Human Immunodeficiency Virus AJNR Am. J. Neuroradiol., January 1, 2008; 29(1): 140 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zivadinov Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis? Neurology, May 29, 2007; 68(22_suppl_3): S72 - S82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Ramio-Torrenta, J Sastre-Garriga, G T Ingle, G R Davies, V Ameen, D H Miller, and A J Thompson Abnormalities in normal appearing tissues in early primary progressive multiple sclerosis and their relation to disability: a tissue specific magnetisation transfer study J. Neurol. Neurosurg. Psychiatry, January 1, 2006; 77(1): 40 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Hurley, T. Ernst, K. Khalili, L. Del Valle, I. L. Simone, and K. H. Taber Identification of HIV-Associated Progressive Multifocal Leukoencephalopathy: Magnetic Resonance Imaging and Spectroscopy J Neuropsychiatry Clin Neurosci, February 1, 2003; 15(1): 1 - 6. [Full Text] [PDF]
|
|
|
|
 |
|
 N F Kalkers, H Vrenken, B M. Uitdehaag, C H Polman, and F Barkhof Brain atrophy in multiple sclerosis: impact of lesions and of damage of whole brain tissue Multiple Sclerosis, October 1, 2002; 8(5): 410 - 414. [Abstract] [PDF]
|
|
|
|
|
|
M. Filippi and R. I. Grossman MRI techniques to monitor MS evolution: The present and the future Neurology, April 23, 2002; 58(8): 1147 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rovira, E. Grive, S. Pedraza, A. Rovira, and J. Alonso Magnetization Transfer Ratio Values and Proton MR Spectroscopy of Normal-appearing Cerebral White Matter in Patients with Liver Cirrhosis AJNR Am. J. Neuroradiol., June 1, 2001; 22(6): 1137 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rovaris, M. Bozzali, G. Santuccio, G. Iannucci, M. P. Sormani, B. Colombo, G. Comi, and M. Filippi Relative contributions of brain and cervical cord pathology to multiple sclerosis disability: a study with magnetisation transfer ratio histogram analysis J. Neurol. Neurosurg. Psychiatry, December 1, 2000; 69(6): 723 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Filippi, M. Bozzali, M. A. Horsfield, M. A. Rocca, M. P. Sormani, G. Iannucci, B. Colombo, and G. Comi A conventional and magnetization transfer MRI study of the cervical cord in patients with MS Neurology, January 11, 2000; 54(1): 207 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Sormani, G. Iannucci, M. A. Rocca, G. Mastronardo, M. Cercignani, L. Minicucci, and M. Filippi Reproducibilty of Magnetization Transfer Ratio Histogram-Derived Measures of the Brainin Healthy Volunteers AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 133 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bozzali, M. A. Rocca, G. Iannucci, C. Pereira, G. Comi, and M. Filippi Magnetization-Transfer Histogram Analysis of the Cervical Cord in Patients with Multiple Sclerosis AJNR Am. J. Neuroradiol., November 1, 1999; 20(10): 1803 - 1808. [Abstract] [Full Text]
|
|
|
|
|
|
A. Rovira, J. Alonso, G. Cucurella, C. Nos, M. Tintoré, S. Pedraza, J. Rio, and X. Montalban Evolution of Multiple Sclerosis Lesions on Serial Contrast-Enhanced T1-Weighted and Magnetization-Transfer MR Images AJNR Am. J. Neuroradiol., November 1, 1999; 20(10): 1939 - 1945. [Abstract] [Full Text]
|
|
|
|
|
|
S M Leary, N C Silver, V L Stevenson, G J Barker, D H Miller, and A J Thompson Magnetisation transfer of normal appearing white matter in primary progressive multiple sclerosis Multiple Sclerosis, October 1, 1999; 5(5): 313 - 316. [Abstract] [PDF]
|
|
|
|
|
|
M. Rocca, Mastronardo, Rodegher, Comi, and Filippi Long-Term Changes of Magnetization Transfer-Derived Measures from Patients with Relapsing-Remitting and Secondary Progressive Multiple AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 821 - 827. [Abstract] [Full Text]
|
|
|
|
|
|
F. Barkhof Imaging of remyelination Multiple Sclerosis, April 1, 1997; 3(2): 129 - 132. [Abstract] [PDF]
|
|